Doctor-designed · Since 1984 · 14,134+ five-star reviews

The fatigue, slow recovery, and stubborn weight after 40 aren't aging.
They're two compounds running dry.

NAD+ and HGH power every system tied to how you feel — energy, recovery, metabolism, muscle. After 40, NAD+ drops 50% and HGH nearly disappears. No amount of sleep or diet compensates. VitalFactors restores both at the source. One effervescent tablet, every morning.

4.8 · 14,134+ five-star reviews

90-day money-back guarantee · Free shipping

As featured on
Why you feel different after 40

Your cells are running
out of fuel

Two compounds — NAD+ and HGH — drive virtually every process tied to energy, recovery, and vitality. After 40, your body quietly stops making enough of either.

50% NAD+ decline by age 60

NAD+ — the cellular energy currency

Nicotinamide Adenine Dinucleotide (NAD+) powers the mitochondria inside every cell. It drives DNA repair, metabolic function, and the conversion of nutrients into usable energy. After 40, NAD+ levels drop by up to 50%. The result: persistent fatigue, slower recovery, and a metabolism that no longer responds the way it once did.

80% HGH decline after age 40

HGH — the repair and recovery signal

Human Growth Hormone coordinates tissue repair, lean muscle maintenance, and fat metabolism. At its peak in your 20s, HGH keeps your body in recovery mode overnight. After 40, natural HGH secretion declines by more than 80%. The byproduct: longer recovery times, loss of lean mass, and the creeping sense that your body just doesn't bounce back the way it used to.

14,134+ five-star reviews
40 yrs nutrition science
90-day money-back guarantee
4.8 average rating
What's inside

Every ingredient serves a purpose.

No fillers. No fluff.

VitalFactors combines precision-dosed NAD+ precursors, HGH-supporting amino acids, and synergistic co-factors — all formulated by MDR's nutrition scientists with 40 years of clinical expertise.

How it works

One glass. Every morning.
That's the whole ritual.

Drop one tablet in water

Each VitalFactors effervescent tablet is pre-dosed with the exact amounts your body needs. Drop it into 8 oz of cold or room-temperature water.

Watch it dissolve

The effervescent formula activates on contact, making nutrients immediately bioavailable — absorbed faster than capsules or powders that must first break down in your gut.

Feel the difference

Most customers report noticeable improvements in energy, mental clarity, and recovery within the first two to three weeks. By week six, the difference is hard to miss.

Chris Cuomo
Celebrity endorsement

"Fitness and nutrition unite for a vibrant, healthy lifestyle. That's why I take Vital Factors as my favorite natural energizer."

What customers say

14,134+ people have
made this their morning

★★★★★

"I've tried every supplement on the market. VitalFactors is the only one where I could actually feel a difference in the first week. Energy is back. Focus is sharper."

Michael R. · Age 54, Tampa FL
★★★★★

"My doctor was skeptical but my bloodwork at 6 months said otherwise. I feel like I'm running on a different engine than I was two years ago."

Sandra K. · Age 61, Phoenix AZ
★★★★★

"I've been taking VitalFactors for 14 months. I workout harder, sleep better, and the mid-afternoon crash I used to dread is completely gone."

James T. · Age 49, Denver CO
★★★★★

"I was 58 and feeling 70. After four months on VitalFactors I feel like I'm 45 again. Not joking. My wife noticed before I did."

Robert M. · Age 58, Austin TX
★★★★★

"The effervescent format is clever — I actually look forward to taking it in the morning. No pill fatigue. And the results speak for themselves."

Linda H. · Age 52, Seattle WA
★★★★★

"Four stars for the first month. Five stars for every month after that. Give it time — it compounds. My recovery from gym sessions is night and day."

David C. · Age 47, Charlotte NC
★★★★★

"90-day guarantee made it a no-brainer to try. I didn't need the guarantee. Still on it 18 months later. Best health decision I've made in my 50s."

Choose your plan

Start your VitalFactors
routine today

40-tablet supply · 40-day cycle · Ships within 24 hours

One-Time Purchase
$99 /bottle
 
  • 40-tablet supply (40 days)
  • Free standard shipping
  • 90-day money-back guarantee
  • No commitment required
  • Standard support
Buy once — $99

No subscription. One-time charge.

All orders backed by MDR's 90-day satisfaction guarantee. If you don't notice a difference, return your bottles for a full refund — no questions asked.

Zero risk

Try it for 90 days.
If you don't feel it, you don't pay.

VitalFactors is backed by MDR's industry-leading 90-day money-back guarantee. If you're not completely satisfied — for any reason — return your bottles and we'll refund every cent. No hassle, no questions, no fine print.

Try risk-free — 90-day guarantee
FAQ

Common questions

Most customers notice improved energy and mental clarity within the first 2–3 weeks. Fuller benefits — including better recovery and sleep quality — typically build over 6–8 weeks. Because VitalFactors works by restoring declining compounds (not stimulating your adrenal system), the results are gradual and lasting rather than a sudden spike and crash.

VitalFactors is formulated with widely studied, naturally occurring compounds. That said, if you're taking prescription medications — particularly blood thinners, diabetes medications, or hormone therapies — consult your physician before starting any new supplement. MDR's customer support team includes nutrition advisors who can answer specific questions.

Effervescent tablets dissolve completely in water before you swallow them — meaning the nutrients are already in solution and begin absorbing immediately in your stomach lining. Traditional capsules and tablets must first break down through digestion, which delays absorption and can reduce bioavailability. The effervescent format gives VitalFactors a meaningful delivery advantage over standard supplements.

Cancellations are handled through your MDR account dashboard — no phone call required. Cancel anytime before your next billing date and you won't be charged again. There are no cancellation fees, no "catch," and no minimum commitment. You can also pause your subscription if you want to skip a month without cancelling entirely.

Yes. VitalFactors is formulated for adults 40 and older regardless of sex. The NAD+ and HGH declines that VitalFactors addresses affect everyone. MDR also offers Fitness Tabs for Men and Fitness Tabs for Women if you want sex-specific micronutrient formulas — these can be taken alongside VitalFactors.

MDR (Medical Doctors' Research) has been formulating clinician-grade supplements for over 40 years. The company is headquartered in Sunrise, FL, and operates a toll-free customer support line staffed by real advisors. VitalFactors is their flagship product and the one Chris Cuomo has publicly endorsed. All MDR formulas are developed by credentialed nutrition scientists — not marketers.

Join 14,134+ customers

Stop accepting the decline.
Start your morning routine.

VitalFactors delivers 40 precision-dosed effervescent tablets — a complete 40-day supply. Order today and notice the difference within weeks, or return it for a full refund. It's that simple.

Try VitalFactors — from $89/mo ★★★★★ 4.8 · 14,134+ reviews · 90-day guarantee